The scientists declared they found a new genetic link between Alzheimer’s disease and diabetes. Researchers found that the gene, known to be present in many Alzheimer’s disease cases, affects the insulin pathway.
Disruption of this pathway is a indication of diabetes. The finding could point to a therapeutic target for both diseases. The scientists have reported : ‘ What we found was that mutations in the worm-equivalent of the APP gene slowed their development, which suggested that some metabolic pathway was disrupted. We began to examine how the worm-equivalent of APP modulated different metabolic pathways and found that the APP equivalent inhibited the insulin pathway. ‘
Scientists have identified genetic link between Alzheimer’s and diabetes
Researchers from the City College of New York made a lot of experiments on worms, they finally have known Alzheimer’s gene also plays a role in the way insulin is processed. A key symptom of Alzheimer’s, which can only be seen after death, is the presence of sticky plaques of amyloid protein in decimated portions of patients’ brains. It is known that mutations in a gene involved in the processing of amyloid protein in Alzheimer’s, which run in families in every generation.
Dr Anne Corbett – Research Communications Manager at Alzheimer’s UK has commented : ‘ However, further research is needed to know whether these findings, from research with worms, will be the same in humans.’
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