{"id":142598,"date":"2013-07-18T21:06:41","date_gmt":"2013-07-18T18:06:41","guid":{"rendered":"http:\/\/www.nationalturk.com\/?p=142598"},"modified":"2013-07-18T21:06:41","modified_gmt":"2013-07-18T18:06:41","slug":"down-sendromu-yeni-umut-142598","status":"publish","type":"post","link":"https:\/\/www.nationalturk.com\/tr\/down-sendromu-yeni-umut-142598\/","title":{"rendered":"Down Sendromu&#8217;nda yeni umut"},"content":{"rendered":"<h1><a href=\"http:\/\/www.nationalturk.com\/tr\/wp-content\/uploads\/2013\/07\/down-sendromu-tedavi.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-142599\" alt=\"Down Sendromu&#039;nda yeni umut\" src=\"http:\/\/www.nationalturk.com\/tr\/wp-content\/uploads\/2013\/07\/down-sendromu-tedavi-280x208.jpg\" width=\"280\" height=\"208\" title=\"\" srcset=\"https:\/\/www.nationalturk.com\/tr\/wp-content\/uploads\/2013\/07\/down-sendromu-tedavi-280x208.jpg 280w, https:\/\/www.nationalturk.com\/tr\/wp-content\/uploads\/2013\/07\/down-sendromu-tedavi-536x400.jpg 536w\" sizes=\"auto, (max-width: 280px) 100vw, 280px\" \/><\/a>Down Sendromu hastalar\u0131 i\u00e7in yeni umut do\u011fdu.<\/h1>\n<p>Down Sendromu&#8217;na\u00a0neden olan fazladan kromozom &#8220;devre d\u0131\u015f\u0131&#8221; b\u0131rak\u0131ld\u0131.<\/p>\n<p>ABD&#8217;deki Massachusetts \u00dcniversitesi&#8217;nden ara\u015ft\u0131rmac\u0131lar, Down Sendromu&#8217;nda rol oynayan 21. kromozom \u00fczerinde \u00e7al\u0131\u015ft\u0131. Down Sendromu&#8217;nda 21. kromozomun iki yerine \u00fc\u00e7 adet bulundu\u011funu belirten bilim adamlar\u0131, laboratuvar ortam\u0131nda fazladan kromozomu etkisiz hale getirmeyi ba\u015fard\u0131.<\/p>\n<p>Ara\u015ft\u0131rmaya imza atanlardan Jeanne Lawrence ve ekibi, Down sendromlu bir hastan\u0131n laboratuvarda \u00fcretilen k\u00f6k h\u00fccrelerine, di\u015fi embriyolarda bulunan iki X kromozomundan birini devre d\u0131\u015f\u0131 b\u0131rakarak, k\u0131z \u00e7ocuklar\u0131n ilave X kromozomu ta\u015f\u0131yan genlere sahip olmas\u0131n\u0131 engelleyen &#8220;XIST&#8221; ad\u0131 verilen geni ekledi.<\/p>\n<p>Ara\u015ft\u0131rma sonunda, genin Down Sendromu&#8217;na neden olan fazladan kromozomu &#8220;devre d\u0131\u015f\u0131&#8221; b\u0131rakt\u0131\u011f\u0131 g\u00f6r\u00fcld\u00fc.<\/p>\n<p>&#8220;Bu mekanizmay\u0131 \u00f6r\u00fcmce\u011fin av\u0131n\u0131 ipek kozas\u0131yla kaplamas\u0131na&#8221; benzeten Lawrence, b\u00fcy\u00fck bir ad\u0131m olan ara\u015ft\u0131rma sonu\u00e7lar\u0131na ra\u011fmen daha kaydedilmesi gereken bir\u00e7ok a\u015fama oldu\u011funu, genleri de\u011fi\u015ftirilen fareler \u00fczerinde bu mekanizman\u0131n test edildi\u011fini vurgulad\u0131.<\/p>\n<p>Ara\u015ft\u0131rma sonu\u00e7lar\u0131 &#8220;Nature&#8221; dergisinde yay\u0131mland\u0131.<\/p>\n<p>\u0130nsanlar\u0131n h\u00fccrelerinde, anne ve babadan gelen 23 \u00e7ift kromozom bulunuyor. Ancak gen bozuklu\u011funa sahip ki\u015filerde, 21&#8217;inci kromozom kendisini e\u015fleyerek ilave bir kromozom ortaya \u00e7\u0131kar\u0131yor. Bu nedenle Down Sendromlu ki\u015filer 46 yerine 47 kromozoma sahip.<\/p>\n<!-- Error, Advert is not available at this time due to schedule\/geolocation restrictions! -->\n","protected":false},"excerpt":{"rendered":"<p>Down Sendromu hastalar\u0131 i\u00e7in yeni umut do\u011fdu.Down Sendromu&#8217;na neden olan fazladan kromozom &#8220;devre d\u0131\u015f\u0131&#8221; b\u0131rak\u0131ld\u0131.<\/p>\n","protected":false},"author":3,"featured_media":178207,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[6155,6669],"tags":[136011,136016],"class_list":["post-142598","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-gundem","category-saglik","tag-down-sendromu","tag-nature-dergisi"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.nationalturk.com\/tr\/wp-json\/wp\/v2\/posts\/142598","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.nationalturk.com\/tr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.nationalturk.com\/tr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.nationalturk.com\/tr\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.nationalturk.com\/tr\/wp-json\/wp\/v2\/comments?post=142598"}],"version-history":[{"count":0,"href":"https:\/\/www.nationalturk.com\/tr\/wp-json\/wp\/v2\/posts\/142598\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.nationalturk.com\/tr\/wp-json\/wp\/v2\/media\/178207"}],"wp:attachment":[{"href":"https:\/\/www.nationalturk.com\/tr\/wp-json\/wp\/v2\/media?parent=142598"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.nationalturk.com\/tr\/wp-json\/wp\/v2\/categories?post=142598"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.nationalturk.com\/tr\/wp-json\/wp\/v2\/tags?post=142598"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}