{"id":147727,"date":"2013-09-13T12:34:07","date_gmt":"2013-09-13T09:34:07","guid":{"rendered":"http:\/\/www.nationalturk.com\/?p=147727"},"modified":"2013-09-13T12:35:02","modified_gmt":"2013-09-13T09:35:02","slug":"turk-bilimadamindan-prostat-kanserine-care-147727","status":"publish","type":"post","link":"https:\/\/www.nationalturk.com\/tr\/turk-bilimadamindan-prostat-kanserine-care-147727\/","title":{"rendered":"T\u00fcrk bilim adam\u0131ndan Prostat kanserine \u00e7are"},"content":{"rendered":"

\"T\u00fcrk<\/a>Oslo ve Harvard \u00fcniversitelerinde \u00e7al\u0131\u015fmalar yapan T\u00fcrk bilim adam\u0131 Prof. Dr. Fahri Saat\u00e7io\u011flu, prostat kanserinde anahtar rol oynayan mekanizmay\u0131 bozacak bir y\u00f6ntem geli\u015ftirerek farelerde prostat kanserini iyile\u015ftirmeyi ba\u015fard\u0131.<\/h1>\n

Oslo \u00dcniversitesi’nde \u00f6\u011fretim \u00fcyesi, Harvard \u00dcniversitesi’nde de misafir ara\u015ft\u0131rmac\u0131 olarak g\u00f6rev yapan Kayserili bilim adam\u0131 Prof. Dr. Saat\u00e7io\u011flu, prostat kanserinde anahtar rol oynayan bir mekanizmay\u0131 ortaya \u00e7\u0131kard\u0131. Saat\u00e7io\u011flu ve ekibi, bu mekanizmay\u0131 bozacak bir y\u00f6ntem geli\u015ftirerek farelerde prostat kanserini iyile\u015ftirmeyi ba\u015fard\u0131.<\/p>\n

Saat\u00e7io\u011flu\u2019nun bu \u00e7al\u0131\u015fmas\u0131, d\u00fcnyada biyoloji bilimleri konusunda \u00f6nde gelen bilimsel dergilerden biri olan Proceedings of National Academy of Sciences’te (PNAS) yay\u0131mland\u0131.<\/p>\n

Prof. Dr. Fahri Saat\u00e7io\u011flu, yapt\u0131\u011f\u0131 yaz\u0131l\u0131 a\u00e7\u0131klamada, bu mekanizman\u0131n merkezinde rol alan KLK4 adl\u0131 geni y\u0131llar \u00f6nce ke\u015ffettiklerini ancak prostat kanserindeki g\u00f6revini bilmediklerini belirtti.<\/p>\n

KLK4\u2019\u00fcn prostata \u00f6zg\u00fcn ekspresyonu oldu\u011funu ve prostat kanser h\u00fccrelerinde b\u00fcy\u00fcmeyi d\u00fczenledi\u011fini de daha \u00f6nce g\u00f6sterdiklerini bildiren Saat\u00e7io\u011flu, \u015funlar\u0131 kaydetti:<\/p>\n

“Bu \u00e7al\u0131smada ise KLK4 proteininin, prostat kanser h\u00fccrelerinin temel sinyal yollar\u0131ndan ikisinin temelinde oldu\u011funu bulduk. \u00d6yle ki h\u00fccre k\u00fclt\u00fcr\u00fcndeki kanser h\u00fccrelerinde KLK4 yap\u0131m\u0131n\u0131 bask\u0131lad\u0131\u011f\u0131m\u0131zda h\u00fccreler b\u00fcy\u00fcme \u00f6zelliklerini kaybettiler ve \u2019apoptoz\u2019 dedigimiz h\u00fccre \u00f6l\u00fcm\u00fcne yakaland\u0131lar. Bu bulgular \u0131\u015f\u0131\u011f\u0131nda Amerika\u2019da MD Anderson Kanser Enstit\u00fcs\u00fcnden Dr. B\u00fclent \u00d6zpolat ile ortak \u00e7al\u0131\u015fma yapt\u0131k. Bu deneylerde insan prostat kanseri t\u00fcm\u00f6rlerini farelerde b\u00fcy\u00fctt\u00fck ve nanoteknolojik bir y\u00f6ntem kullanarak geli\u015ftirdi\u011fimiz KLK4 bask\u0131lay\u0131c\u0131 formulasyonu do\u011frudan kana verdi\u011fimizde t\u00fcm\u00f6rlerin birka\u00e7 hafta i\u00e7inde k\u00fc\u00e7\u00fcl\u00fcp hemen hemen yok oldu\u011funu g\u00f6rd\u00fck. Amac\u0131m\u0131z bu y\u00f6ntemi optimize ederek en k\u0131sa zamanda prostat kanserli hastalarda denemek.\u2019\u2019<\/p>\n

Prof. Dr. Saat\u00e7io\u011flu, bu bulgular\u0131n kendilerini bilimsel anlamda \u00e7ok heyecanland\u0131rd\u0131\u011f\u0131n\u0131 belirterek, “Prostat kanserinde ilk defa b\u00f6ylesine temel ve detayl\u0131 bir mekanizmay\u0131 ortaya \u00e7\u0131kard\u0131\u011f\u0131m\u0131z i\u00e7in prostat kanser h\u00fccrelerinin molek\u00fcler ve h\u00fccresel yap\u0131s\u0131n\u0131 daha iyi anlayabilece\u011fiz. Buna ek olarak, bu mekanizmay\u0131 kullanarak insanlarda prostat kanserini tedavi etme olana\u011f\u0131 \u00e7\u0131kt\u0131\u011f\u0131ndan, bulgular\u0131m\u0131z\u0131n hem temel \u00e7al\u0131\u015fmalar ve hem de klini\u011fe y\u00f6nelik uygulamalar a\u00e7\u0131s\u0131ndan \u00f6nemli oldu\u011funu d\u00fc\u015f\u00fcn\u00fcyorum\u2019\u2019 ifadelerini kulland\u0131.<\/p>\n

“Yoga, genleri de\u011fi\u015ftirerek ba\u011f\u0131\u015f\u0131kl\u0131k sistemini g\u00fc\u00e7lendiriyor”<\/h2>\n

Prof. Dr. Fahri Saat\u00e7io\u011flu, ba\u015fka bir \u00e7al\u0131\u015fmada, yogan\u0131n genleri de\u011fi\u015ftirerek ba\u011f\u0131\u015f\u0131kl\u0131k sistemini g\u00fc\u00e7lendirdi\u011fini ortaya \u00e7\u0131kard\u0131klar\u0131n\u0131 bildirdi.<\/p>\n

Bu konuda yapt\u0131klar\u0131 \u00e7al\u0131\u015fman\u0131n biyolojik bilimlerde tan\u0131nm\u0131\u015f bir dergi olan Plos One’da yay\u0131mland\u0131\u011f\u0131n\u0131 aktaran Saat\u00e7io\u011flu, yogik hareketler, yogik nefes ve meditasyondan olu\u015fan iki saatlik bir yoga program\u0131n\u0131n kandaki ba\u011f\u0131\u015f\u0131kl\u0131k sistemi h\u00fccrelerinde genetik d\u00fczeyde etkili oldu\u011funu tespit ettiklerini a\u00e7\u0131klad\u0131.<\/p>\n

Saat\u00e7io\u011flu, \u015fu bilgileri verdi:<\/p>\n

\u201cDenekler g\u00fcn\u00fcn ayn\u0131 saatinde, ya 2 saatlik bir yoga program\u0131 ya da do\u011fa y\u00fcr\u00fcy\u00fc\u015f\u00fc ve sonras\u0131nda rahatlat\u0131c\u0131 m\u00fczik dinledikleri kontrol program\u0131n\u0131 uygulad\u0131lar. Ayn\u0131 denekler iki yoga veya iki kontrol program\u0131n\u0131 ayr\u0131 g\u00fcnlerde (toplam d\u00f6rt g\u00fcn) uygulad\u0131lar. Programlara ba\u015flamadan ve hemen sonras\u0131nda deneklerden kan ald\u0131k, ba\u011f\u0131\u015f\u0131kl\u0131k h\u00fccrelerini ayr\u0131\u015ft\u0131rd\u0131k ve bu h\u00fccrelerde genomik metodlar\u0131 kullanarak t\u00fcm genlerde olabilecek ekspresyon de\u011fi\u015fikliklerini belirledik. Yogaya \u00f6zg\u00fc 97 genin ekspresyonunda de\u011fi\u015fiklik olu\u015furken, hafif spor ve rahatlama kontrol program\u0131 sadece 24 geni etkiledi. Yani yoga program\u0131 kontrole g\u00f6re \u00e7ok daha etkili oldu genetik d\u00fczeyde. Bu bulgular yogik hareketlerin faydalar\u0131n\u0131n hemen pratik s\u0131ras\u0131nda ba\u015flad\u0131\u011f\u0131n\u0131 ve fizyolojimizin en temel d\u00fczeyi olan DNA molek\u00fcl\u00fcndeki genetik bilgilerin nas\u0131l kullan\u0131l\u0131r hale geldi\u011fini g\u00f6steriyor. Bu pratikler uzun vadede h\u00fccre biyolojisi ve \u00fcst d\u00fczey fizyolojideki sa\u011fl\u0131k etkileri i\u00e7in temel olu\u015fturabilir.\u2019\u2019<\/p>\n\n","protected":false},"excerpt":{"rendered":"

T\u00fcrk bilim adam\u0131 Prof. Dr. Fahri Saat\u00e7io\u011flu, prostat kanserinde anahtar rol oynayan mekanizmay\u0131 bozacak bir y\u00f6ntem geli\u015ftirerek farelerde prostat kanserini iyile\u015ftirmeyi ba\u015fard\u0131.<\/p>\n","protected":false},"author":3,"featured_media":177365,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[6155,5005,6669,6224,6805,6662],"tags":[38376,38379,38378,133598],"class_list":["post-147727","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-gundem","category-manset","category-saglik","category-teknoloji","category-turkiye","category-yasam","tag-prostat-kanseri","tag-prostat-kanseri-tedavi","tag-prostat-kanseri-tedavisi","tag-turk-bilim-adami"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.nationalturk.com\/tr\/wp-json\/wp\/v2\/posts\/147727","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.nationalturk.com\/tr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.nationalturk.com\/tr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.nationalturk.com\/tr\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.nationalturk.com\/tr\/wp-json\/wp\/v2\/comments?post=147727"}],"version-history":[{"count":0,"href":"https:\/\/www.nationalturk.com\/tr\/wp-json\/wp\/v2\/posts\/147727\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.nationalturk.com\/tr\/wp-json\/wp\/v2\/media\/177365"}],"wp:attachment":[{"href":"https:\/\/www.nationalturk.com\/tr\/wp-json\/wp\/v2\/media?parent=147727"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.nationalturk.com\/tr\/wp-json\/wp\/v2\/categories?post=147727"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.nationalturk.com\/tr\/wp-json\/wp\/v2\/tags?post=147727"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}