![\"\u015eeker](\"http:\/\/www.nationalturk.com\/tr\/wp-content\/uploads\/2018\/08\/seker-hastalarina-mujde-tek-dozda-iyilestiren-ilac-.jpg\" "\\"\\"")
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Akdeniz \u00dcniversitesi (A\u00dc) Gen ve H\u00fccre Tedavi Merkezi M\u00fcd\u00fcr\u00fc Prof. Dr. Salih \u015eanl\u0131o\u011flu ile \u00e7al\u0131\u015fma arkada\u015flar\u0131 Prof. Dr. Mustafa Kemal Balc\u0131, Prof. Dr. Hasan Ali Altunba\u015f, Prof. Dr. Thomas Griffith, Prof. Dr. Ahter \u015eanl\u0131o\u011flu, ara\u015ft\u0131rma g\u00f6revlileri Hale Ta\u015fy\u00fcrek ve Yunus Emre Ek\u015fi taraf\u0131ndan y\u00fcr\u00fct\u00fclen 5 y\u0131ll\u0131k proje sonunda, \u015feker hastal\u0131\u011f\u0131na kar\u015f\u0131 yeni nesil gen tedavi ila\u00e7lar\u0131 geli\u015ftirildi. Yeni nesil ila\u00e7lar\u0131n tek dozda \u015feker hastal\u0131\u011f\u0131n\u0131 iyile\u015ftirici \u00f6zelli\u011fi oldu\u011fu, bunun d\u00fcnyada bir ilk oldu\u011fu kaydedildi.<\/p>\n
Prof. Dr. Salih \u015eanl\u0131o\u011flu, geli\u015ftirilen ilac\u0131 ilk olarak fareler \u00fczerinde denediklerini kaydetti. Prof. Dr. \u015eanl\u0131o\u011flu, \u00f6ncelikle deney hayvanlar\u0131n\u0131 y\u00fcksek kalorili \u00f6zel i\u00e7erikli yemle besleyerek, insanlarda obezite kaynakl\u0131 Tip 2 diyabet bulgular\u0131n\u0131 taklit eden, ins\u00fclin direnci, glukoz tolerans bozuklu\u011fu ve kan \u015fekeri y\u00fcksekli\u011fiyle seyreden bir model olu\u015fturduklar\u0131n\u0131 s\u00f6yledi.<\/p>\n
Prof. Dr. \u015eanl\u0131o\u011flu, obez deneklere gen aktar\u0131m\u0131n\u0131n ins\u00fclin direncini k\u0131rd\u0131\u011f\u0131n\u0131, glukoz tolerans\u0131n\u0131 iyile\u015ftirdi\u011fini, kan ya\u011flar\u0131n\u0131 azaltarak diyabet geli\u015fimini tamam\u0131yla engelledi\u011finin tespit edildi\u011fini a\u00e7\u0131klad\u0131. Prof. Dr. \u015eanl\u0131o\u011flu, bu \u00e7al\u0131\u015fman\u0131n sonu\u00e7lar\u0131n\u0131n da Nature Gene Therapy dergisinin 2018 y\u0131l\u0131 Temmuz say\u0131s\u0131nda yay\u0131mlanarak dergiye kapak konusu oldu\u011funu s\u00f6yledi.<\/p>\n
Prof. Dr. \u015eanl\u0131o\u011flu, \u015fu an d\u00fcnya \u00e7ap\u0131nda \u015feker hastal\u0131\u011f\u0131na kar\u015f\u0131 geli\u015ftirilme a\u015famas\u0131nda \u00e7ok say\u0131da ila\u00e7 oldu\u011funu, bunlar aras\u0131nda FDA onayl\u0131 GLP-1 Resept\u00f6r Agonistleri diye bilinen yeni nesil ila\u00e7lar\u0131n en etkili antidiyabetik ajanlar olarak kabul g\u00f6rd\u00fc\u011f\u00fcn\u00fc belirtti.<\/p>\n
Prof. Dr. \u015eanl\u0131o\u011flu, Diyabet hastalar\u0131, ilgili ila\u00e7lar\u0131 hayatlar\u0131 boyunca her g\u00fcn kendilerine enjekte etmek zorunda. Biz yapt\u0131\u011f\u0131m\u0131z \u00e7al\u0131\u015fma ile bu ila\u00e7lar\u0131n gen formunu gen nakil vekt\u00f6rlerine klonlayarak, tek bir enjeksiyonla hastalar\u0131n \u00f6m\u00fcr boyu bu ila\u00e7lar\u0131 kullanma zorunluluklar\u0131n\u0131 ortadan kald\u0131rma potansiyeli olan yeni bir gen terapi ilac\u0131 geli\u015ftirdik” diye konu\u015ftu.<\/p>\n
Prof. Dr. \u015eanl\u0131o\u011flu, geli\u015ftirilen ilac\u0131n diyabetin en \u00f6nemli bulgular\u0131 olan ins\u00fclin diren\u00e7lili\u011fini k\u0131rd\u0131\u011f\u0131n\u0131, beta h\u00fccre fonksiyon bozuklu\u011funu d\u00fczeltti\u011fini ve kan \u015fekerini beta h\u00fccre rejenerasyonu yoluyla d\u00fc\u015f\u00fcrerek kilo kayb\u0131na yol a\u00e7t\u0131\u011f\u0131n\u0131 g\u00f6zlemlediklerini belirtti. Prof. Dr. \u015eanl\u0131o\u011flu, pankreas h\u00fccrelerini yeniden programlama \u00f6zelli\u011fi de olan gen nakil \u00e7al\u0131\u015fmas\u0131n\u0131n, ABD’deki Human Gene Therapy dergisinde Temmuz ay\u0131nda yay\u0131mland\u0131\u011f\u0131 bilgisini de payla\u015ft\u0131.<\/p>\n
Bir sonraki a\u015famada bu \u00e7al\u0131\u015fmaya ili\u015fkin onay ald\u0131ktan sonra geli\u015ftirilen gen terapi ilac\u0131yla \u00f6nce diyabete yakalanm\u0131\u015f hasta kedilerin tedavi edilmesinin planland\u0131\u011f\u0131n\u0131 aktaran Prof. Dr. \u015eanl\u0131o\u011flu, Gen ve H\u00fccre Tedavi Merkezi olarak nihai hedeflerinin ise klinik denemeler, yani benzer \u00e7al\u0131\u015fmalar\u0131n diyabetli insanlarda da yap\u0131labilmesi oldu\u011funu ifade etti.<\/p>\n
Hem Avrupa, hem de ABD’de farkl\u0131 hastal\u0131klarda kullan\u0131m\u0131 yeni onaylanm\u0131\u015f (metabolik hastal\u0131klar, ba\u011f\u0131\u015f\u0131kl\u0131k yetmezlik sendromu, kan kanseri ve k\u00f6rl\u00fck) gen ve h\u00fccre tedavi \u00fcr\u00fcnleri oldu\u011funu belirten Prof. Dr. \u015eanl\u0131o\u011flu, bu ila\u00e7lar\u0131n ortalama fiyat\u0131n\u0131n 1 milyon dolar civar\u0131nda oldu\u011funu s\u00f6zlerine ekledi.<\/p>\n
Diyabeti tek dozda iyile\u015ftiren ila\u00e7lar\u0131 ise d\u00fcnyada ilk kez kendilerinin \u00fcretti\u011fini aktaran Prof. Dr. \u015eanl\u0131o\u011flu, bu yeni nesil ila\u00e7lar\u0131n fiyat\u0131n\u0131n y\u00fcksek olmas\u0131n\u0131n temel nedeninin katma de\u011feri y\u00fcksek, ileri teknoloji \u00fcr\u00fcn\u00fc olmas\u0131n\u0131n yan\u0131nda, tek dozla hastal\u0131\u011fa kesin \u00e7\u00f6z\u00fcm imkan\u0131 sunmas\u0131 oldu\u011funu belirtti. \u00dclkemiz insan\u0131na bu tedavi imkan\u0131n\u0131 sunabilmenin tek yolunun yeni nesil gen ve h\u00fccre tedavi ila\u00e7lar\u0131n\u0131 kendi merkezlerinde \u00fcretebilmek oldu\u011funu s\u00f6yleyen Prof. Dr. \u015eanl\u0131o\u011flu, yerli ila\u00e7 geli\u015ftirme \u00e7al\u0131\u015fmalar\u0131na \u00f6nem verilmesi gerekti\u011fini vurgulad\u0131.<\/p>\n\n","protected":false},"excerpt":{"rendered":"
\u015eeker hastalar\u0131na m\u00fcjde! Tek dozla iyile\u015ftiren ila\u00e7lar geli\u015ftirildi. Akdeniz \u00dcniversitesi Gen ve H\u00fccre Tedavi Merkezi b\u00fcnyesinde y\u00fcr\u00fct\u00fclen T\u00dcB\u0130TAK projeleri kapsam\u0131nda, d\u00fcnyada ilk kez \u015feker hastal\u0131\u011f\u0131n\u0131 tek doz uygulamayla iyile\u015ftiren yeni nesil gen tedavi ila\u00e7lar\u0131 geli\u015ftirildi. Deney a\u015famalar\u0131n\u0131n s\u00fcrd\u00fc\u011f\u00fc, nihai hedefin insanlar \u00fczerinde kullan\u0131lmas\u0131 oldu\u011fu ifade edildi. Akdeniz \u00dcniversitesi (A\u00dc) Gen ve H\u00fccre Tedavi Merkezi M\u00fcd\u00fcr\u00fc …<\/p>\n","protected":false},"author":9192198,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[763,5005,6669,349,6805],"tags":[2754,11670],"class_list":["post-268761","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-gunun-olayi","category-manset","category-saglik","category-son-dakika","category-turkiye","tag-akdeniz-universitesi","tag-tubitak"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.nationalturk.com\/tr\/wp-json\/wp\/v2\/posts\/268761","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.nationalturk.com\/tr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.nationalturk.com\/tr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.nationalturk.com\/tr\/wp-json\/wp\/v2\/users\/9192198"}],"replies":[{"embeddable":true,"href":"https:\/\/www.nationalturk.com\/tr\/wp-json\/wp\/v2\/comments?post=268761"}],"version-history":[{"count":0,"href":"https:\/\/www.nationalturk.com\/tr\/wp-json\/wp\/v2\/posts\/268761\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.nationalturk.com\/tr\/wp-json\/wp\/v2\/media?parent=268761"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.nationalturk.com\/tr\/wp-json\/wp\/v2\/categories?post=268761"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.nationalturk.com\/tr\/wp-json\/wp\/v2\/tags?post=268761"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}