Pittsburgh \u00dcniversitesi T\u0131p Fak\u00fcltesi’ndeki ara\u015ft\u0131rmac\u0131lar bug\u00fcn umut verici yeni bir COVID-19 a\u015f\u0131 aday\u0131 geli\u015ftirdiklerini a\u00e7\u0131klad\u0131lar. Erken hayvan denemeleri \u015fimdiye kadar \u00fcmit vaat ediyor, ancak insan denemeleri hala planlama a\u015famas\u0131nda. <\/p>\n
EBioMedicine dergisinde yay\u0131nlanan hakemli makalenin k\u0131demli yazar\u0131 ve Pittsburgh T\u0131p Fak\u00fcltesi’nde cerrahi profes\u00f6r\u00fc olan Andrea Gambotto, “2003’te SARS-CoV ve 2014’te MERS-CoV hakk\u0131nda daha \u00f6nce deneyime sahiptik. SARS-CoV-2 ile yak\u0131ndan ili\u015fkili olan bu iki vir\u00fcs, bize ba\u015fak proteini ad\u0131 verilen belirli bir proteinin, vir\u00fcse kar\u015f\u0131 ba\u011f\u0131\u015f\u0131kl\u0131\u011f\u0131 tetiklemek i\u00e7in \u00f6nemli oldu\u011funu \u00f6\u011fretiyor. Bu yeni vir\u00fcsle tam olarak nerede sava\u015faca\u011f\u0131m\u0131z\u0131 biliyorduk” ifadelerini kulland\u0131.<\/p>\n
“PittCoVacc” (Pittsburgh Coronavirus Vaccine) olarak adland\u0131r\u0131lan a\u015f\u0131, grip a\u015f\u0131s\u0131 ile ayn\u0131 temel yolla \u00e7al\u0131\u015f\u0131yor.<\/p>\n
Laboratuar yap\u0131m\u0131 viral protein par\u00e7alar\u0131n\u0131 v\u00fccuda enjekte ederek bir ba\u011f\u0131\u015f\u0131kl\u0131k olu\u015fturmay\u0131 ama\u00e7l\u0131yor.<\/p>\n
PittCoVacc a\u015f\u0131s\u0131 farelerde test edildi\u011finde, ara\u015ft\u0131rmac\u0131lar \u00f6l\u00fcmc\u00fcl SARS-CoV \u2013 2 vir\u00fcs\u00fcn\u00fc n\u00f6tralize edebilen antikor say\u0131s\u0131n\u0131n iki hafta i\u00e7inde artt\u0131\u011f\u0131n\u0131 ke\u015ffettiler.<\/p>\n
Yeni ila\u00e7, bir i\u011fne yoluyla iletilmek yerine, bir mikroi\u011fne dizisi, 400 k\u00fc\u00e7\u00fck mikroi\u011fneden olu\u015fan bir Bant Yard\u0131m\u0131 benzeri yama yoluyla uygulan\u0131yor. Yama uyguland\u0131ktan sonra, tamamen \u015feker ve proteinden yap\u0131lan mikroi\u011fneler \u00e7\u00f6z\u00fcl\u00fcyor ve geride hi\u00e7bir iz b\u0131rakm\u0131yor. <\/p>\n
Ara\u015ft\u0131rmac\u0131lara g\u00f6re, bu yamalar end\u00fcstriyel \u00f6l\u00e7ekte b\u00fcy\u00fck “h\u00fccre fabrikalar\u0131nda” kolayca \u00fcretilebilir. A\u015f\u0131n\u0131n depolama veya ta\u015f\u0131ma s\u0131ras\u0131nda so\u011futulmas\u0131na bile gerek olmad\u0131\u011f\u0131 belirtiliyor.<\/p>\n
Gambotto, “\u00c7o\u011fu a\u015f\u0131ya ba\u015flamak i\u00e7in \u00f6l\u00e7eklenebilirli\u011fi ele alman\u0131za gerek yoktur. Ama bir pandemiye kar\u015f\u0131 h\u0131zl\u0131 bir \u015fekilde a\u015f\u0131 geli\u015ftirmeye \u00e7al\u0131\u015ft\u0131\u011f\u0131n\u0131zda ilk \u015fart budur” diyor.<\/p>\n
\u0130nsan denemelerine ba\u015flamadan \u00f6nce, ara\u015ft\u0131rmac\u0131lar \u015fu anda ABD G\u0131da ve \u0130la\u00e7 \u0130daresi’nden ila\u00e7 onay\u0131 i\u00e7in ba\u015fvuru yapm\u0131\u015f durumda. <\/p>\n
Profes\u00f6r Louis Falo, “Hastalardaki test s\u00fcreci en az bir y\u0131l, muhtemelen daha uzun s\u00fcrecektir. Bu \u00f6zel durum \u015fimdiye kadar g\u00f6rd\u00fc\u011f\u00fcm\u00fcz her \u015feyden farkl\u0131, bu nedenle klinik geli\u015fim s\u00fcrecinin ne kadar s\u00fcrece\u011fini bilmiyoruz” a\u00e7\u0131klamas\u0131nda bulundu.<\/p>\n\n","protected":false},"excerpt":{"rendered":"
Pittsburgh \u00dcniversitesi T\u0131p Fak\u00fcltesi’ndeki ara\u015ft\u0131rmac\u0131lar bug\u00fcn umut verici yeni bir COVID-19 a\u015f\u0131 aday\u0131 geli\u015ftirdiklerini a\u00e7\u0131klad\u0131lar. Erken hayvan denemeleri \u015fimdiye kadar \u00fcmit vaat ediyor, ancak insan denemeleri hala planlama a\u015famas\u0131nda. EBioMedicine dergisinde yay\u0131nlanan hakemli makalenin k\u0131demli yazar\u0131 ve Pittsburgh T\u0131p Fak\u00fcltesi’nde cerrahi profes\u00f6r\u00fc olan Andrea Gambotto, “2003’te SARS-CoV ve 2014’te MERS-CoV hakk\u0131nda daha \u00f6nce deneyime sahiptik. …<\/p>\n","protected":false},"author":4,"featured_media":288913,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[6155,763,5005,349],"tags":[1887,220661,220418,220460],"class_list":["post-288912","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-gundem","category-gunun-olayi","category-manset","category-son-dakika","tag-abd","tag-gunun-olayi","tag-koronavirus","tag-koronavirus-asisi"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.nationalturk.com\/tr\/wp-json\/wp\/v2\/posts\/288912","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.nationalturk.com\/tr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.nationalturk.com\/tr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.nationalturk.com\/tr\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/www.nationalturk.com\/tr\/wp-json\/wp\/v2\/comments?post=288912"}],"version-history":[{"count":0,"href":"https:\/\/www.nationalturk.com\/tr\/wp-json\/wp\/v2\/posts\/288912\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.nationalturk.com\/tr\/wp-json\/wp\/v2\/media\/288913"}],"wp:attachment":[{"href":"https:\/\/www.nationalturk.com\/tr\/wp-json\/wp\/v2\/media?parent=288912"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.nationalturk.com\/tr\/wp-json\/wp\/v2\/categories?post=288912"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.nationalturk.com\/tr\/wp-json\/wp\/v2\/tags?post=288912"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}